What is NMN?
NMN also known as Nicotinamide Mononucleotide. The scientific names is called β -nicotinamide Mononucleotide. It is a derivative of vitamin B3. The structure of NMN can be divided into α and β isomers, of which β-NMN is the natural form and has biological activity. Nicotinamide mononucleotide (NMN) is the direct precursor of nicotinamide adenine dinucleotide (NAD+).
NMN is a naturally occurring substance that is found in all human beings and living organisms. Organic NMN is available in a variety of foods such as avocados, cucumber, and broccolis; however, and the amount of NMN in food is too minimal. It is nearly impossible for human being to have the desired anti aging effects with normal consumption in food.
NAD+ is also called nicotinamide adenine dinucleotide, which is present in every living cell and is involved in thousands of biochemical reactions. Nicotinamide adenine dinucleotide (NAD+) plays an important role in many cellular metabolic reactions and is an important element for cell viability.
NAD+ in the human body is reduced by half approximately every 20 years. The decline of NAD as we age is considered to be the main cause of diseases and illnesses, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiency, arthritis caused by autoimmune inflammatory response disorders, metabolic disorders and cardiovascular diseases. As we age chronologically, the decreased NAD+ levels lead to lowering DNA repair ability. And the result of accumulation of DNA damage drives the aging process.
Benefits of boosting NAD+ by taking NMN
NMN is the direct precursor to NAD. When you take NMN, your body will quickly absorbed from the gut into your bloodstream. Here are the benefits of taking NMN supplements:
Combat Aging: Helps to support healthy cellular aging, and combat the age-related decline of NAD+.
Lowers Risk of Obesity: NMN administration significantly and dose-dependently suppressed age-associated body weight gain.
Promotes Vascular Health and Blood Flow: NMN protects our cells from the damage that occurs with old age, such as stiffening blood vessels and oxidative stress which can lead to countless other health problems in later life.
Improves Energy Muscle Endurance and Strength: NMN provide extended periods of time of energy metabolism. (over 80% of our consumers felt boost of energy after 2 weeks of NMN intake)
Can I take NAD+?
NAD+ is a large molecule that is cannot be directly absorbed and utilized by the human body. If you take NAD+ directly, it will be hydrolyzed by cells in the small intestine. The best way to supplement NAD+ is to find a natural way to supplement NAD, so that it can synthesize NAD+ in the human body. There are three pathways for NAD+ synthesis in humans: preiss-Handler pathway, de novo synthesis pathway and remedial synthesis pathway. Although NAD+ can be synthesized by all three pathways, not all two pathways are efficient. NAD+ produced by the first two pathways only accounts for approximately 15% of NAD+ in our body, and the remaining 85% is achieved through remedial synthesis. In other words, the remedial synthetic pathway is the key to NAD+ supplementation
The three main precursors pathway to NAD+ are NAM nicotinamide, NR nicotinamide ribosomes and NMN; however, among the three, NMN is the direct precursor pathway to NAD+ in which it is a better molecule to supplement.
How NMN is produced?
There are three main methods in producing NMN, which are through chemical synthesis, fermentation and biological enzyme method.
Fermentation method
Fermentation is a common way to produce NMN, but it's not very efficient and the cost of production is very high. Fermentation also produces lower yields than other methods; in additionally, fermentation based NMN has short shelf life because they degrade easily when exposed to air or light (which would cause them break down).
Chemical Synthesis Method
This method has much lower technical barrier to produce and the cost of production is relatively cheap compared to the other two methods. However, this method is not able to produce high purity NMN and the process leaves residue. Although the amount of residue is very minor, but long-term intake can potentially be harmful to your body.
Biological Enzyme Method
It is to emulate the natural metabolism path in your body. It simulates a natural biological enzymic reaction to produce NMN. This method is like how your body create NMN naturally and thus able to produce NMN above 99% purity. This method does not involve any additional chemical material to perform. It is considered safest but difficult to perform because of the technical barriers. NUNMN only deliver NMNs that derivates from biological enzyme method and promises to deliver the highest quality NMN in the market.
|
Method |
Chemical Synthesis |
Fermentation |
Biological enzyme |
|
Technical Barriers |
Low |
High |
High |
|
Safety |
Low |
High |
High |
|
Cost |
Low |
High |
Relatively High |
|
Organic Residue |
Yes |
No |
No |
|
Purity |
Low |
High |
High |
|
Contamination |
High |
Low |
Low |
How to choose NMN supplement?
Ingredients
The first thing you should look at when choosing NMN supplement is the ingredients. Make sure that it only contains nicotinamide mononucleotide without any other ingredients or substances which could potentially affect NMN’s potency and effectiveness.
Purity
You should also make sure that the supplement you choose is pure. This means it will be free of contaminants and other substances which could potentially harm your body. One easy rule is to look for NMN with purity over 99%.
Label
The label of the supplement should list the ingredients, dosage instructions for use. If you are buying NMN in Canada, make sure that this product is produced under GMP (Good Manufacturing Practice) standards with an appropriate NPN Natural Product Number on its packaging. GMP standards ensures that products are consistently produced and controlled according to quality standards. NPN is a product licence that is issued by Health Canada to ensure the safety, effectiveness, and the quality of the product.
Brand
Brand is very important. You would want to make sure that you're buying from a reputable brand with high-quality products, so do some research on the company before purchasing anything!
Where to buy NMN supplement in Canada?
NMN supplement is a very new product in the market. Many retail stores across Canada have never heard of this supplement, which makes it difficult for people who wants to buy it. NUNMN Nulab Technology Ltd is one of the very first company that produces NMN and market them legally in Canada. Most of the NMN brands do not have NPN natural health product license to produce and sell NMN in Canada, because they are difficult to obtain.
NUNMN is now available for purchase through the online shop! Now you can get your supplement of choice delivered straight to you with minimal effort.
Should I take NMN supplement?
The answer may vary depending on who you ask. Generally speaking, people take NMN supplements because they believe that it can help them in some way. Some people take NMN supplements for their anti-aging properties, as NMN has been shown to help improve cellular function and slow down the aging process. Others take NMN supplements for energy, as it can help improve metabolism and increase ATP production. And still others take NMN supplements for general health purposes, as it is a powerful antioxidant that can help protect cells from damage and improve overall cellular function. No matter what your reason is for taking NMN supplements, it is always important to speak with your advisor before starting any new supplement, as they can help you determine if NMN is right for your specific health needs.
